Flushing Meadows, NY (Sports Network) - Former top-10 star James Blakes singles career came to an end on a rainy Wednesday at the U.S. Open. Ivo Karlovic of Croatia fired 38 aces past Blake to claim a 6-7 (2-7), 3-6, 6-4, 7-6 (7-2), 7-6 (7-2) victory in a match that lasted over three hours. Blakes only other first-round loss here came in 1999. "I dont know when its going to hit me. I dont think Ill be sleeping a lot tonight," Blake said. Blake announced Monday that this would be his last tournament. The 33-year-old American ended his career with 10 singles titles. He reached the quarterfinals at the U.S. Open in 2005 and 2006 and Australian Open in 2008, and also landed in the final at the Tennis Masters Cup in 2006. "Its hitting me now Im never going to have this again in my life, a teary- eyed Blake said. "That ovation makes me realize every bit of hard work is worth it." In 2004, while practicing with fellow American Robby Ginepri in Rome, Blake broke his neck when he slipped on a clay court and collided with the net post. In July of that year, his father died of stomach cancer. At the same time, Blake developed shingles, which temporarily paralyzed half his face and blurred his sight. Blake was the ATPs Comeback Player of the Year in 2005 and was named the Arthur Ashe Humanitarian of the Year in 2008. Meanwhile, defending champion Andy Murray and former title winner Juan Martin del Potro posted first-round wins on Wednesday. The third-seeded Murray cruised past French left-hander Michael Llodra 6-2, 6-4, 6-3. The reigning Wimbledon and U.S. Open titlist beat Novak Djokovic in last years final in Flushing and was a runner-up here in 2008. Murray will next do battle with Leonardo Mayer, who took down Victor Hanescu 7-6 (7-4), 6-4, 3-6, 7-6 (7-4). The sixth-seeded 2009 champion del Potro snuck past Guillermo Garcia-Lopez by a 6-3, 6-7 (5-7), 6-4, 7-6 (9-7) margin in a match that lasted over four hours on a rainy Wednesday. Garcia-Lopez saved three match points in the final tiebreaker before del Potro put him away. The last time del Potro came into the U.S. Open seeded No. 6 was four years ago and he went on to capture the title. Next up for del Potro is former world No. 1 Lleyton Hewitt, who defeated American Brian Baker by a 6-3, 4-6, 6-3, 6-4 score. Hewitt, who captured the U.S. Open in 2001 and was the 2004 runner-up to Roger Federer, improved his impressive record at Flushing Meadows to 44-11. Stanislas Wawrinka, the No. 9 seed, discarded Czech Radek Stepanek 7-6 (7-2), 6-3, 6-2. The 28-year-old Wawrinka will take on Karlovic in the second round. American Rajeev Ram upset 16th-seeded Italian Fabio Fognini 6-1, 6-2, 6-2. He will play Marcel Granollers in the second round. Granollers outlasted Jurgen Zopp 6-1, 3-6, 1-6, 6-3, 6-4. No. 17 seed Kevin Anderson, No. 20 seed Andreas Seppi and No. 21 seed Mikhail Youzhny avoided the upset bug. Anderson took down Daniel Brands 7-5, 4-6, 6-2, 6-3, Seppi beat Xavier Malisse 6-3, 3-6, 7-5, 7-5 and Youzhny got past Nicolas Mahut 6-4, 6-4, 7-6 (7-4). Evgeny Donskoy cruised past 29th-seeded Austrian Jurgen Melzer 7-5, 6-3, 7-6 (7-3), while Russian Alex Bogomolov Jr. outlasted 24th-seeded Frenchman Benoit Paire 7-5, 2-6, 6-4, 5-7, 7-6 (7-5). Other first-round wins came from former Australian Open runner-up and former top-10 star Marcos Baghdatis, Peter Gojowczyk, Tim Smyczek, Alexandr Dolgopolov, Somdev Devvarman. Cheap MLB Jerseys .Y. -- Barry Bonds, Roger Clemens, Sammy Sosa and Mark McGwire will have less time to remain eligible for the Hall of Fame ballot under changes made Saturday. Cheap Mariners Jerseys . The Oilers have been shut out in three straight home games and are in last place in the Western Conference with a 4-14-2 record. "Things have obviously not gone as well as I would have thought probable. http://www.cheapmarinersjerseys.com/ . Patty Mills had 20 points, Tim Duncan had 11 points and 13 rebounds in limited action, and San Antonio rolled to a 110-82 victory over Milwaukee that kept the Bucks winless in the new year. Wholesale Mariners Jerseys . - The Mavericks built a 12-point lead with 2:50 to play, gave away all but two points of it, and still managed to hang on. Cheap Seattle Mariners Jerseys .C. -- Carter Ashton had a pair of goals and added an assist as the Toronto Marlies downed the Charlotte Checkers 5-2 on Saturday in the American Hockey League.RIMOUSKI, Que. -- Frederik Gauthier scored twice and tacked on an assist as the Rimouski Oceanic extended their win streak to 11 games by defeating the visiting Rouyn-Noranda Huskies 5-2 on Saturday in Quebec Major Junior Hockey League action. Sebastien Sylvestre scored once and set up three more for the Oceanic (40-15-7) while Peter Trainor and Alexis Loiseau each added a goal and an assist. Jean-Sebastien Dea and Mathieu Lemay supplied the scoring for the Huskies (33-24-5), who are on a three-game slide. Philippe Desrosiers made 38 saves for Rimouski as Rouyn-Norandas Alexandre Belanger stopped 20-of-24 shots in defeat. --- DRAKKAR 5 TIGRES 1 BAIE-COMEAU, Que. -- Jeremy Gregoire had two goals and an assist as the Drakkar toppled Victoriaville. Robbie Graham, Gabryel Paquin-Boudreau and Valentin Zykov also scored for Baie-Comeau (44-15-4). Drakkar netminder Philippe Cadorette made 29 saves for the win. Jean-Francois Plante scored the lone goal for the Tigres (31-24-7) while Francois Tremblay turned away 44 shots in a losing cause. --- TITAN 3 ISLANDERS 2 (SO) BATHURST, N.B. -- Christophe Boivin forced extra time with a goal at 19:57 of the third period and then scored the shootout winner as the Titan edged Charlottetown. Raphael Lafontaine also sscored for Acadie-Bathurst (19-37-6) and Scott Oke had two assists.dddddddddddd Alexandre Goulet and Anthony Cortese scored for the Islanders (19-36-7). Jacob Brennan made 28 saves for the Titan. Charlottetowns Mason McDonald stopped 27-of-29 shots in defeat. --- MOOSEHEADS 5 WILDCATS 2 MONCTON, N.B. -- Nikolaj ehlers registered a hat trick for the second straight game as Halifax beat the Wildcats for its seventh straight win. Philippe Gadoury and Matt Murphy also scored for the Mooseheads (41-18-3) while Jonathan Drouin and Brent Andrews each had three assists. Will Smith and Ivan Barbashev responded for Moncton (30-30-3), which is on a five-game skid. Zachary Fucale turned away 34 shots for Halifax as Alex Dubeau made 28 saves for the Wildcats. --- SEA DOGS 9 SCREAMING EAGLES 3 SAINT JOHN, N.B. -- Marcus Cuomo, Noah Zilbert and Oliver Cooper each scored twice as the Sea Dogs hammered Cape Breton. Jurij Repe had a goal and two assists for Saint John (19-37-5) and David Weckworth and Spencer Smallman added the others. The Screaming Eagles (33-25-4) got goals from Charles-Eric Legare, Maxim Lazarev and Julien Pelletier. Sebastien Auger made 37 saves for the Sea Dogs while Cape Bretons Alex Bureau gave up all nine goals on 27 shots. 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